The supervillain Megamind finally defeats his nemesis, the superhero Metro Man. But without a hero, he loses all purpose and must find new meaning to his life. After super-villain Megamind (Ferrell) kills his good-guy nemesis, Metro Man (Pitt), he becomes bored since there is no one left to fight. He creates a new foe, Tighten (Hill), who, instead of using his powers for good, sets out to destroy the world, positioning Megamind to save the day for the first time in his life.