The supervillain Megamind finally defeats his nemesis, the superhero Metro Man. But without a hero, he loses all purpose and must find new meaning to his life. After super-villain Megamind (Ferrell) kills his good-guy nemesis, Metro Man (Pitt), he becomes bored since there is no one left to fight. He creates a new foe, Tighten (Hill), who, instead of using his powers for good, sets out to destroy the world, positioning Megamind to save the day for the first time in his life.

A sausage strives to discover the truth about his existence. The products at Shopwell's Grocery Store are made to believe a code that helps them live happy lives until it's time for them to leave the comfort of the supermarket and head for the great beyond. However, after a botched trip to the great beyond leaves one sausage named Frank and his companion Bun stranded, Frank goes to great lengths (pun intended) to return to his package and make another trip to the great beyond. But as Frank's journey takes him from one end of the supermarket to the other, Frank's quest to discover the truth about his existence as a sausage turns incredibly dark. Can he expose the truth to the rest of the supermarket and get his fellow products to rebel against their human masters?