The supervillain Megamind finally defeats his nemesis, the superhero Metro Man. But without a hero, he loses all purpose and must find new meaning to his life. After super-villain Megamind (Ferrell) kills his good-guy nemesis, Metro Man (Pitt), he becomes bored since there is no one left to fight. He creates a new foe, Tighten (Hill), who, instead of using his powers for good, sets out to destroy the world, positioning Megamind to save the day for the first time in his life.

The sailor of legend is framed by the goddess Eris for the theft of the Book of Peace, and must travel to her realm at the end of the world to retrieve it and save the life of his childhood friend Prince Proteus. A Persian sailor named Sinbad is on a quest to find the magical legendary Book of Peace, a mysterious artifact that Eris, the Greek wicked goddess of chaos, has ultimately framed him for stealing! If he fails on this quest, his childhood friend Prince Proteus of Syracuse will take Sindbad's death penalty, while Eris gains a desired foothold of power in the world of mortals.