Red Riding Hood is training in the group of Sister Hoods, when she and the Wolf are called to examine the sudden mysterious disappearance of Hansel and Gretel. Hood vs. Evil will find a teen such as Red Riding Hood who will be training in a distant land with a mysterious, covert group called the Sister Hoods. When Red and the Wolf get called upon by Nick Flippers the head of the Happily Ever After Agency over to investigate the disappearance of Hansel and Gretel.

Little Red Riding Hood, the Wolf, the Woodsman, and Granny all tell the police the events that lead up to their encounter. The candy recipes of the goody shops have been stolen by the Goody Bandit, and many animals are out of business. While the police are chasing the criminal, there is a mess at Granny's house involving Little Red Hiding Hood, The Wolf, The Woodsman and Granny, disturbing the peace in the forest. They are all arrested by the impatient Chief Grizzly. Detective Nicky Flipper is in charge of the investigation, and each accused gives his/her own version of the incident. Flipper uses the information to disclose the identity of the evil Goody Bandit.